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MRP1 expression in a subset of patients with breast cancer may be associated with the resistance to standard adjuvant cyclophosphamide, methotrexate, fluorouracil chemotherapy, but it does not alter the response to tamoxifen and goserelin.

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For instance, the results from two prospective phase II trials have revealed that high-dose sequential chemotherapy followed by autologous peripheral blood stem cell transplantation resulted in an estimated 12-year overall, disease- and event-free survival of 34, 55, and 30%, respectively, in 46 patients diagnosed with advanced stage peripheral T-cell lymphomas.

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Such an approach would be possible only in a multinational trial because of the rareness of this disease.

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La parte successiva dello XX secolo inoltre ha veduto lo sviluppo delle terapie mirate a come gli inibitori di fattore di crescita come trastuzumab (Herceptin), gefitinib (Iressa), imatinib (Gleevec) e cetuximab (Erbitux).

The disease was first called cancer by Greek physician Hippocrates (460-370 BC).

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As a consequence of these failures to prolong the lives of NSCLC patients, AstraZeneca withdrew its European Marketing Authorization Application for Iressa on January 4, 2005.

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In NSCLC cell lines both TKIs have similar micromolar (μM) inhibitory concentrations.

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The impact of treatment on disease-related symptoms and quality of life was evaluated with Chinese version of European Organization for Research and Treatment of Cancer-Quality of Life Core Questionnaire-30 (EORTC QLQ-C30) and QLQ-LC13.

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The first EML4-ALK NSCLC patient enrolled in the trial was a 49-year-old male never-smoker enrolled onto the 300 orally twice a day cohort on December 26, 2007 at Massachusetts General Hospital, Boston, MA, barely 4 months after publication of the Soda et al paper.

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