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Newer agents, like aromatase inhibitors, may be more effective than tamoxifen in both early and advanced stages of breast cancer.

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Compared to these therapies, treatment with antiandrogens exhibits "fewer hot flashes, less of an effect on libido, less muscle wasting, fewer personality changes, and less bone loss.

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In some cases this causes vision loss and other health problems that might have been avoided had a timely diagnosis been made.

On the basis of mammography sensitivity (or thresholds of detection), screening identifies disease in the preclinical screening-detection period and results in the identification of earlier-stage or smaller tumors than might be identified by clinical detection, resulting in reduction in breast cancer mortality.

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