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PFS estimates were made using the Kaplan-Meier method (), and the 95% confidence interval (CI) for the median was based on the sign test.

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MRP1 expression in a subset of patients with breast cancer may be associated with the resistance to standard adjuvant cyclophosphamide, methotrexate, fluorouracil chemotherapy, but it does not alter the response to tamoxifen and goserelin.

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The results from a phase I trial revealed that the combined use of MS-209 with docetaxel does not significantly affect the non-hematological and hematological toxicities and has little effect on pharmacokinetics of docetaxel in a group of patients with advanced and metastatic cancers.

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For instance, the results from two prospective phase II trials have revealed that high-dose sequential chemotherapy followed by autologous peripheral blood stem cell transplantation resulted in an estimated 12-year overall, disease- and event-free survival of 34, 55, and 30%, respectively, in 46 patients diagnosed with advanced stage peripheral T-cell lymphomas.

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Such an approach would be possible only in a multinational trial because of the rareness of this disease.

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La parte successiva dello XX secolo inoltre ha veduto lo sviluppo delle terapie mirate a come gli inibitori di fattore di crescita come trastuzumab (Herceptin), gefitinib (Iressa), imatinib (Gleevec) e cetuximab (Erbitux).

The disease was first called cancer by Greek physician Hippocrates (460-370 BC).

Furthermore, the detection of cytokeratin 19 (CK-19) and of mRNA-positive circulating tumor cells (CTCs) in the peripheral blood and the bone marrow of patients with breast cancer is correlated with increased incidence of relapse.

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Recent studies reported that breast cancer patients who received a taxane-containing chemotherapy regimen had a significantly higher incidence of CNS metastases compared with that of patients treated with a nontaxane-containing regimen.

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If IRESSA is approved, for the first time patients with these types of tumours will have a better alternative to chemotherapy as a first-line treatment.

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The incidence of anal cancer increases with age: patients with anal cancer have an average (median) age of 62 years.

As a consequence of these failures to prolong the lives of NSCLC patients, AstraZeneca withdrew its European Marketing Authorization Application for Iressa on January 4, 2005.

Further no benefit of dose escalation over 69.

In NSCLC cell lines both TKIs have similar micromolar (μM) inhibitory concentrations.

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The impact of treatment on disease-related symptoms and quality of life was evaluated with Chinese version of European Organization for Research and Treatment of Cancer-Quality of Life Core Questionnaire-30 (EORTC QLQ-C30) and QLQ-LC13.

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In December 2015, AstraZeneca filed an answer including counterclaims that Sanofi's proposed lixisenatide product would infringe several AstraZeneca patents.

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The first EML4-ALK NSCLC patient enrolled in the trial was a 49-year-old male never-smoker enrolled onto the 300 orally twice a day cohort on December 26, 2007 at Massachusetts General Hospital, Boston, MA, barely 4 months after publication of the Soda et al paper.

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Tumor barcode signals were scaled to corresponding barcode signals of the injected cell mixture to determine the number of cell equivalents; the scaled signal for each barcode line was then used to determine the percentage contribution of each tumor cell line to the mixture.

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By inhibiting IDO1 and decreasing kynurenine in tumor cells, this agent increases tryptophan levels, restores the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, T-lymphocytes, and causes a reduction in tumor-associated regulatory T-cells (Tregs).

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After a total of about eight months of treatment The cancer was "no longer discernible" in the lymph nodes and the original tumor in the left lung has shrunk considerably.

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Mahmoud Al-Hawary, MD, Associate Professor of Radiology; Director, Gastrointestinal Radiology Service, Abdominal Radiology Division of the Michigan Comprehensive Cancer Center, Ann Arbor, discussed the role of these three imaging modalities.

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